TSH-receptor, antibodies

The thyroid is a small, butterfly-shaped gland in the neck, in front of the trachea. It primarily produces thyroid hormones, namely thyroxine (T4) and triiodothyronine (T3), to regulate the speed of energy consumption. The secretion of hormones is regulated by TSH or thyroid-stimulating hormone.

The thyroid produces hormones that regulate our metabolism. Our immune system, on the other hand, produces antibodies when we contract certain illnesses.

Sometimes, the immune system accidentally starts to produce antibodies that affect the thyroid. These are called TSH receptor antibodies or TSHRAb (Thyroid-Stimulating Hormone Receptor Antibody). The antibodies stimulate the thyroid to produce thyroid hormones in excess, resulting in hyperthyroidism. The antibodies may also prevent thyroid functions, causing hypothyroidism.

When should TSHRAb be measured?

THSRAb is usually measured when examining the reasons for hyperthyroidism. Hyperthyroidism caused by thyroid-stimulating antibodies is called Basedow's disease.

Hyperthyroidism may cause the following symptoms:

• Sweating
• Fatigue
• Irritability
• Muscle weakness
• Heart palpitations
• Weight loss
• Overactive bowel movements
• Thirst
• Disturbances of the menstrual cycle

What does the TSHRAb test measure?

The test measures the blood for TSH receptor antibodies. The test cannot be used to find out whether the antibodies are causing hyperthyroidism or hypothyroidism.

The test is typically used to find the reason for and monitoring the treatment of hyperthyroidism.