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S -E2

Symptoms of menopause typically manifest as the stopping of menstrual periods, hot flashes, sweating, and thinning of membranes. When oestrogen levels decrease, the skin also loses flexibility, as oestrogens regulate the production of collagen. The body’s normal ageing-related changes can accelerate. The risk of cardiovascular diseases increases, as does the risk of osteoporosis.

Oestrogens consist of hormones that regulate women’s sex characteristics and fertility. The name oestrogen is derived from the Greek “oistros”, meaning heat, and “genos”, meaning "producer of”. Oestradiol, oestrone, and oestriol are often the three main oestrogens. The most important of them is oestradiol (S-E2), which is produced in the ovaries, adrenal glands, and placenta. Oestradiol affects many functions in a woman’s body, such as reproduction, the brain, bone density, liver, heart, mammary glands, uterus, and vagina.

Even though oestradiol is often perceived as a female hormone, men also produce small amounts of E2 hormone in the testicles and the adrenal cortex. In men’s bodies, the E2 hormone affects the muscles, bones, brain, fat, and cholesterol metabolism.

When is a good time to measure oestradiol levels?

It is a good idea to measure the concentration of oestradiol in women when wanting to examine:

  • functioning of the ovaries
  • disturbances of the menstrual cycle
  • timing of ovulation
  • infertility
  • early or late puberty
  • unclear sweating and sleep disorders
  • monitoring of oestrogen therapy
  • a hormone-producing tumour in the ovaries
  • bleeding during menopause

It is a good idea to measure the concentration of oestradiol in men when wanting to examine:

  • breast growth in men
  • possible testosterone deficiency
What does an oestradiol test measure?

The test measures the level of oestradiol hormone in the blood at the time of sampling. The level of oestradiol varies according to the menstrual cycle and at different ages. In the early phases of becoming a woman, oestradiol influences the start of menstrual periods and breast development. When menopause begins, the level of E2 hormone first decreases and then its secretion stops altogether. In children, the level of E2 hormone is usually low.

In women with menstrual periods, the level of oestradiol has to be proportioned to the current stage of the cycle.

Normally, the result is: 


  •  Follicular phase  0,08 – 0,92 nmol/l
  •  Ovulation surge  0,14 – 2,38 nmol/l
  •  Luteal phase  0,08 – 1,15 nmol/l
  •  Postmenopause   < 0,1 nmol/l

Men: < 0,16 nmol/l

The reference values of this examination have changed 6.10.2022. You will find your own result's reference values from My LOUNA in touch with the graph. Read more about defining reference values.

Please contact your physician or other healthcare professional if you suspect an illness or need help interpreting the results.

In women, high oestradiol levels can be caused by:

  • a tumour in the ovaries
  • early puberty
  • bleeding during menopause.

Correspondingly, men’s high levels can indicate:

  • enlarging of the breasts
  • teratoma
  • an adrenal or testicular tumour.

Low levels of oestradiol are caused by:

  • disturbances of the menstrual cycle, such as missing a menstrual period
  • progesterone deficiency
  • Follicle stimulating hormone affects the growth and maturation of eggs (1422 S-FSH)
  • Luteinising hormone regulates gametes and sex hormones (2265 S-LH)
  • Progesterone prepares the lining of the uterus for pregnancy (2502 S-Prog)

SYNLAB tests: Oestradiol https://www.yml.fi/tuotekuvaus_show.php?tuotenro=119

Avain Apteekit Terveys: Estrogeenien monet tehtävät

Terveysportti: Kuukautisia edeltävä oireyhtymä ja dysforinen häiriö: https://www.duodecimlehti.fi/duo11201

Terveyskirjasto, Normaali kuukautiskierto https://www.terveyskirjasto.fi/dlk00158/normaali-kuukautiskierto?q=kuukautiskierto

Terveyskylä, Raskauden alkaminen https://www.terveyskyla.fi/naistalo/lis%C3%A4%C3%A4ntymisterveys/hedelm%C3%A4llisyys/raskauden-alkaminen


Fasting is not required

This examination does not require fasting